1.
researchsquare; 2024.
Preprint
in English
| PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-4176871.v1
ABSTRACT
COVID-19 continues to cause significant morbidity and mortality, with emerging strains rapidly spreading despite substantial immunity through vaccination and previous exposure. Animal models that accurately reflect COVID-19 are vital for testing mechanisms of disease, enabling development of improved vaccines and therapeutics. We have developed human ACE2 transgenic pigs that are highly susceptible to SARS-CoV-2 and display clinical signs, disease progression, and lung inflammation that faithfully replicate severe COVID-19 in humans.